Phentermine Hydrochloride Tablets are indicated as a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index 30 kg/m2, or 27 kg/m2 in the presence of other risk factors (e.g., controlled hypertension, diabetes, hyperlipidemia). ADIPEX-P (phentermine hydrochloride) tablets, for oral use CIV ADIPEX-P (phentermine hydrochloride) capsules, for oral use CIV Initial U.S. Approval: 1959 The drug is classified under a certain chemical class known as amphetamine as it has a similar pharmacology value to other drugs classified in the class. See DrugAbuse and Dependence (9.3). Nationwide Efforts to Combat the Problem Questions To Discuss At the completion of this block of instruction you will be able to answer the following questions: 1. Phentermine is not to be used while pregnant or breastfeeding under any circumstances. Metabolism Phentermine has two metabolic pathways; hydroxylation and oxidation. It is illegal and unsafe to buy phentermine without a prescription. The board expressed concerns that removing the prescribing restrictions could lead to misuse of weight loss drugs such as phentermine. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. With respect to the care and treatment of patients with obesity, APRNs are required to incorporate the State Medical Board rules applicable to physicians and prescribing practices. When mental impairment is present while taking Phentermine, a patient is also advised not to drive to avoid the risk of being involved in an accident. Any knowledge would be most appreciated. Lomaira: One tablet three times a day, taken 30 minutes before meals. Talk with your doctor before starting an exercise program. Phentermine is related chemically and pharmacologically to amphetamine (d- and dll-amphetamine) and other related stimulant drugs have been extensively abused. The overdose symptoms include: The side effects of Phentermine can lead to several symptoms that may impair certain functions in the patients body. Or it can help you feel full longer. Safety and effectiveness in pediatric patients have not been established. The recommended maximum dosage of Phentermine is 15 mg daily for patients with severe renal impairment (eGFR 15 to 29 mL/min/1.73m2). Some weight loss clinics also insist that patients take additional supplements, such as vitamin B12 shots and 5-HTP, to boost phentermine despite the supplements unproven effectiveness. It is impossible for them to complete the necessary physical evaluation (and follow-up) that is required to ensure that phentermine will not cause you undue harm. These lifestyle changes often include participating in regular exercise and physical activities, as well as eating a well-balanced diet that does not contain large amounts of calories or harmful substances. Current Obesity Reports. ). The rate of weight loss is greatest in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks. Many patients find that if their doctor gradually lowers their dose, for example from 37.5mg per day down to 15mg per day for the last few days, they experience fewer withdrawal symptoms and are able to keep the weight off later. The doctor also looks at the patients medical history for any pre-existing medical conditions that the medication should not be taken with. health information, we will treat all of that information as protected health Ideally, patients should take it on an empty stomach. (2012). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Manifestations of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states. Use of Phentermine is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis. Management of acute Phentermine hydrochloride intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Plus, the doctors are not familiar with your overall health status, instead relying entirely on self-reported information, which is often incomplete or inaccurate. Although phentermine is the agent-of-choice among physicians specializing in obesity treatment, the use of this drug for obesity treatment by other physicians has long been curtailed because misapprehensions regarding phentermine safety. In order to determine the effectiveness of certain pharmaceuticals, supplements and other substances, clinical trials and scientific research are often conducted among a group of volunteers. 4 = Before taking phentermine, tell your doctor and pharmacist if you are allergic to phentermine, any other medications, or any of the ingredients in phentermine tablets. N;d0)zQ|,]8EtXy(En"GX omjU3Y3>kfkYHYi]-zhm{= o`i$G1BK%?9Z+(dm`mKt,?;6K@Q 7}}*Tw>7BkKsJ;E|Viexb T-3j%5QB%wI5'$5oB :h*C"Q7yjTzLO%6QS/u>HX 4DGz*A!1*p"7$-joX2YF8ht@\l[&LS$FU=udM&y.l_ Dr. Lazarus, we will discuss combination phentermine therapy later in this roundtable discussion. 6 Our members represent more than 60 professional nursing specialties. Trends in Prescribing and Dispensing Patterns . So some health care providers might order it for longer use. Phentermine is 17.5% plasma protein-bound, while topiramate is 15 - 41% plasma protein-bound when the blood concentration range is 0.5 to 250 g/mL. Click here for an email preview. Tablets containing 37.5 mg Phentermine hydrochloride (equivalent to 30 mg Phentermine base). This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Yes, phentermine is a federally controlled substance because it may be abused or lead to 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Phentermine is approved for short-term weight loss therapy. PDF Reference ID: 3115694 - Food and Drug Administration Since Phentermine is a drug that contains chemical compounds, it is important to know about all of the risks that are involved with its use and precautions a person should be aware of before the consumption. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Overdosage of pharmacologically similar compounds has resulted in fatal poisoning usually terminates in convulsions and coma. The final option is online doctors who prescribe phentermine. It isnt prescribed on request, but rather when a healthcare provider notices it may be beneficial for a specific patient to lose weight in order to improve their overall health or to decrease the risk of certain health concerns. other information we have about you. IBM Micromedex. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Advise pregnant women and nursing mothers not to use Phentermine [see Use in Specific Populations (8.1, 8.3)]. endstream endobj 1531 0 obj <>/Metadata 26 0 R/Pages 1528 0 R/StructTreeRoot 41 0 R/Type/Catalog>> endobj 1532 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 0/Tabs/S/TrimBox[0.0 0.0 630.0 702.0]/Type/Page>> endobj 1533 0 obj <>stream A doctor is the only person who can determine if phentermine is right for you. Patients are advised to report any symptoms or diseases they may have before the doctor prescribes the drug this may include high blood pressure and kidney problems, as well as any type of diabetes and thyroid disorders. According to the medical board, at this time, only physicians who prescribe opioids are receiving benchmark style reports and the board thinks that all prescribers who report into OARRS should receive the same information. 1 Unpublished raw data. Phentermine is intended to help overweight and obese patients who have already tried losing weight with diet and exercise. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Phentermine doctors network. Patients must be instructed on how much Phentermine to take, and when and how to take it [see Dosage and Administration (2)]. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. But regarding phentermine monotherapy, phentermine hydrochloride (HCl) is a sympathomimetic Drug Enforcement Agency (DEA) scheduled IV drug approved as an anti-obesity medication and marketed in the US since 1959 (See Table 1).The reported weight reduction efficacy of phentermine [10] derived from . It's designed to help prevent opioid dependence for Ohio's injured workers through its three primary goals. Patients must be informed about the risks of use of Phentermine (including the risks discussed in Warnings and Precautions), about the symptoms of potential adverse reactions and when to contact a physician and/or take other action. Many people live far away from their nearest weight loss clinic, which can make follow-ups complicated. Phentermine, an amphetamine congener, is the most widely used anti-obesity drug in the U.S. information is beneficial, we may combine your email and website usage information with %PDF-1.6 % It is not uncommon for patients to experience a change in their sexual interest. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Use caution in prescribing Phentermine for patients with even mild hypertension (risk of increase in blood pressure). Phentermine was later provided to patients in combination with dexfenfluramine and fenfluramine as a more powerful appetite suppressant that could also act as a fat burner. . Facts & Comparisons eAnswers. Want to get more tips, information, and motivation? Moreover, it is strongly recommended to avoid or limit the alcohol intake. It can help weight loss by making you less hungry. BMI is calculated by taking the patients weight, in kilograms (kg), divided by the patients height, in meters (m), squared. Phentermine hydrochloride/topiramate. PDF ADI-40091 Adipex-P PI v2 As a result, they may be more open to the idea of prescribing phentermine. Not only can losing weight harm an unborn baby during pregnancy, but the drug may also cause adverse effects. Phentermine is a Schedule 4 drug. Avoid use of Phentermine in patients with eGFR less than 15 mL/min/1.73m2 or end-stage renal disease requiring dialysis [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. ), Cannot find a doctor in your network that prescribes phentermine. Long-term Phentermine Pharmacotherapy: An Investigation for Symptoms of The combined drug is approved for long-term use. The MAO inhibitors (Monoamine Oxidase Inhibitors) are used to treat depression, especially a specific type called atypical depression. 1558 0 obj <>/Filter/FlateDecode/ID[<7182559B062CF74D9CEE71C953F61692>]/Index[1530 62]/Info 1529 0 R/Length 121/Prev 89015/Root 1531 0 R/Size 1592/Type/XRef/W[1 2 1]>>stream 5 If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus. Cumulative urinary excretion of Phentermine under uncontrolled urinary pH conditions was 62% to 85%. However, if it is almost time for your next dose, skip the missed dose and go back to your . In a single-dose study comparing the exposures after oral administration of a combination capsule of 15 mg Phentermine and 92 mg topiramate to the exposures after oral administration of a 15 mg Phentermine capsule or a 92 mg topiramate capsule, there is no significant topiramate exposure change in the presence of Phentermine. While suffering from any of these health concerns may be a cause for concern, it does not mean a patient will not be able to use Phentermine at all. information is beneficial, we may combine your email and website usage information with Special Populations Geriatric Patients Select dosage with caution, starting at lower end of dosage range. How to Get a Prescription for Phentermine - Phentermine.com Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. endstream endobj 105 0 obj <> endobj 106 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]>>/Rotate 0/Type/Page>> endobj 107 0 obj <>stream Following the administration of Phentermine, Phentermine reaches peak concentrations (Cmax) after 3 to 4.4 hours. Find out everything you need to know about weight loss drugs in our prescription weight loss pill guide. - 7 There are reports of patients who have increased the dosage of these drugs to many times than recommended. Encourage prescribers to incorporate best clinical practices when prescribing opioids for treating Ohio . If obesity is impacting your fertility or reproductive health, or if you have a specific condition that affects weight (such as PCOS), your gynecologist may consider prescribing phentermine as a short-term weight management strategy. endstream endobj startxref Press Releases. potentially hazardous activities such as operating machinery or driving FULL PRESCRIBING INFORMATION in the presence of other risk factors (e.g., controlled hypertension, 333-33-100411 Tasks 35 Phentermine: 18.75 to 37.5 milligrams (mg) once a day, taken before breakfast or 1 to 2 hours after breakfast. Phentermine also is offered combined with topiramate for weight loss (Qsymia). The patient brings in a prescription for the same drug on November 1, 2013. The additional boost in energy will also increase the physical activity levels, thereby providing an additional method for them to lose weight and gain overall health benefits. information submitted for this request. 2 information and will only use or disclose that information as set forth in our notice of I hold a DEA cert. Dispense in a tight container as defined in the USP, with a child-resistant closure (as required). This content does not have an English version. The prescribing designation for anorexiants can be located on page 15 of The Formulary Developed by the Committee on Prescriptive Governance (The Formulary).

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